Magnetic resonance imaging (MRI), or nuclear magnetic resonance imaging (NMRI), is primarily a noninvasive medical imaging Medical imaging is the technique and process used to create images of the human body for clinical purposes (medical procedures seeking to reveal, diagnose or examine disease) or medical science (including the study of normal anatomy and physiology). Although imaging of removed organs and tissues can be performed for medical reasons, such technique used in radiology Radiologists are physicians that utilize an array of imaging technologies (such as ultrasound, computed tomography , nuclear medicine, positron emission tomography (PET) and magnetic resonance imaging (MRI)) to diagnose or treat diseases. Interventional radiology is the performance of (usually minimally invasive) medical procedures with the to visualize detailed internal structure and limited function of the body. MRI provides much greater contrast Contrast is the difference in visual properties that makes an object distinguishable from other objects and the background. In visual perception of the real world, contrast is determined by the difference in the color and brightness of the object and other objects within the same field of view. Because the human visual system is more sensitive to between the different soft tissues of the body than computed tomography Computed tomography is a medical imaging method employing tomography created by computer processing. Digital geometry processing is used to generate a three-dimensional image of the inside of an object from a large series of two-dimensional X-ray images taken around a single axis of rotation (CT) does, making it especially useful in neurological Neurology is a medical specialty dealing with disorders of the nervous system. Specifically, it deals with the diagnosis and treatment of all categories of disease involving the central, peripheral, and autonomic nervous systems, including their coverings, blood vessels, and all effector tissue, such as muscle. The corresponding surgical specialty (brain), musculoskeletal The human musculoskeletal system is an organ system that gives humans and animals the ability to move using the muscular and skeletal systems. The musculoskeletal system provides form, stability, and movement to the human and animal body, cardiovascular, and oncological Oncology (from the Ancient Greek onkos , meaning bulk, mass, or tumor, and the suffix -logy (-λογία), meaning "study of") is a branch of medicine that deals with tumors (cancer). A medical professional who practices oncology is an oncologist (cancer) imaging.

Unlike CT, MRI uses no ionizing radiation Ionizing radiation consists of subatomic particles or electromagnetic waves that are energetic enough to detach electrons from atoms or molecules, ionizing them. The occurrence of ionization depends on the energy of the impinging individual particles or waves, and not on their number. An intense flood of particles or waves will not cause. Rather, it uses a powerful magnetic Magnetism, a non-contact force, is a category of behaviour of materials that respond at an atomic or subatomic level to an applied magnetic field. For example, the most well known form of magnetism is ferromagnetism such that some ferromagnetic materials produce their own persistent magnetic field. However, all materials are influenced to greater field to align the nuclear magnetization The nuclear magnetic moment is the magnetic moment of an atomic nucleus and arises from the spin of the protons and neutrons. It is mainly a magnetic dipole moment; the quadrupole moment does cause some small shifts in the hyperfine structure as well of (usually) hydrogen Hydrogen is the chemical element with atomic number 1. It is represented by the symbol H. With an average atomic weight of 1.00794 u (1.007825 u for Hydrogen-1), hydrogen is the lightest and most abundant chemical element, constituting roughly 75 % of the Universe's elemental mass. Stars in the main sequence are mainly composed of hydrogen in its atoms The atom is a basic unit of matter that consists of a dense, central nucleus surrounded by a cloud of negatively charged electrons. The atomic nucleus contains a mix of positively charged protons and electrically neutral neutrons . The electrons of an atom are bound to the nucleus by the electromagnetic force. Likewise, a group of atoms can remain in water in the body. Radio frequency Radio frequency is a rate of oscillation in the range of about 30 kHz to 300 GHz, which corresponds to the frequency of electrical signals normally used to produce and detect radio waves. RF usually refers to electrical rather than mechanical oscillations, although mechanical RF systems do exist (see mechanical filter and RF MEMS) (RF) fields are used to systematically alter the alignment of this magnetization. This causes the hydrogen nuclei to produce a rotating magnetic field detectable by the scanner. This signal can be manipulated by additional magnetic fields to build up enough information to construct an image of the body.[1]:36

Magnetic resonance imaging is a relatively new technology. The first MR image was published in 1973[2][3] and the first cross-sectional image of a living mouse was published in January 1974.[4] The first studies performed on humans were published in 1977.[5][6] By comparison, the first human X-ray X-radiation is a form of electromagnetic radiation. X-rays have a wavelength in the range of 0.01 to 10 nanometers, corresponding to frequencies in the range 30 petahertz to 30 exahertz (3 × 1016 Hz to 3 × 1019 Hz) and energies in the range 120 eV to 120 keV. They are shorter in wavelength than UV rays and longer than gamma rays. In many image was taken in 1895.

Magnetic resonance imaging is a development of nuclear magnetic resonance Nuclear magnetic resonance is a property that magnetic nuclei have in a magnetic field and applied electromagnetic (EM) pulse or pulses, which cause the nuclei to absorb energy from the EM pulse and radiate this energy back out. The energy radiated back out is at a specific resonance frequency which depends on the strength of the magnetic field. Originally, the technique was referred to as nuclear magnetic resonance imaging (NMRI). However, because the word nuclear was associated in the public mind with ionizing radiation Ionizing radiation consists of subatomic particles or electromagnetic waves that are energetic enough to detach electrons from atoms or molecules, ionizing them. The occurrence of ionization depends on the energy of the impinging individual particles or waves, and not on their number. An intense flood of particles or waves will not cause exposure, it is generally now referred to simply as MRI. Scientists still use the term NMRI when discussing non-medical devices operating on the same principles. The term magnetic resonance tomography (MRT) is also sometimes used.

Contents

How MRI works

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Main article: Physics of Magnetic Resonance Imaging

The body is largely composed of water molecules Gutyon's Textbook of Medical Physiology states that "the total amount of water in a man of average weight is approximately 40 liters, averaging 57 percent of his total body weight. In a newborn infant, this may be as high as 75 percent of the body weight, but it progressively decreases from birth to old age, most of the decrease occurring. Each water molecule has two hydrogen Hydrogen is the chemical element with atomic number 1. It is represented by the symbol H. With an average atomic weight of 1.00794 u (1.007825 u for Hydrogen-1), hydrogen is the lightest and most abundant chemical element, constituting roughly 75 % of the Universe's elemental mass. Stars in the main sequence are mainly composed of hydrogen in its nuclei The nucleus is the very dense region consisting of nucleons at the center of an atom. Almost all of the mass in an atom is made up from the protons and neutrons in the nucleus, with a very small contribution from the orbiting electrons. It was discovered in 1911, as a result of Ernest Rutherford's interpretation of the famous 1909 Rutherford or protons The proton is a subatomic particle with an electric charge of +1 elementary charge. It is found in the nucleus of each atom, along with neutrons, but is also stable by itself and has a second identity as the hydrogen ion, H+. It is composed of three fundamental particles: two up quarks and one down quark. When a person goes inside the powerful magnetic field Magnetic fields surround magnetic materials and electric currents and are detected by the force they exert on other magnetic materials and moving electric charges. The magnetic field at any given point is specified by both a direction and a magnitude ; as such it is a vector field of the scanner, the magnetic moments The magnetic moment of a magnet is a measure of its tendency to align with a magnetic field. Both the magnetic moment and magnetic field may be considered to be vectors having a magnitude and direction. The direction of the magnetic moment points from the south to north pole of a magnet. The magnetic field produced by a magnet is proportional to of some of these protons changes, and aligns with the direction of the field.

In an MRI machine a radio frequency transmitter is briefly turned on, producing an electromagnetic field The electromagnetic field is a physical field produced by electrically charged objects. It affects the behavior of charged objects in the vicinity of the field. The electromagnetic field extends indefinitely throughout space and describes the electromagnetic interaction. It is one of the four fundamental forces of nature (the others are. The photons of this field have just the right energy, known as the resonance frequency, to flip the spin In particle physics and quantum mechanics, spin is a fundamental characteristic property of elementary particles, composite particles , and atomic nuclei.[notes 1] of the aligned protons in the body. As the intensity In physics, intensity is a measure of the energy flux, averaged over a certain time period. The word "intensity" here is not synonymous with "strength", "amplitude", or "level", as it sometimes is in colloquial speech. For example, "the intensity of pressure" is meaningless, since the parameters of and duration of application of the field increase, more aligned spins are affected. After the field is turned off, the protons decay to the original spin-down state and the difference in energy between the two states is released as a photon. It is these photons that produce the electromagnetic signal that the scanner detects. The frequency the protons resonate at depends on the strength of the magnetic field. As a result of conservation of energy The law of conservation of energy is an empirical law of physics. It states that the total amount of energy in an isolated system remains constant over time . A consequence of this law is that energy can neither be created nor destroyed, it can only be transformed from one state to another. The only thing that can happen to energy in a closed, this also dictates the frequency of the released photons. The photons released when the field is removed have an energy — and therefore a frequency — due to the amount of energy the protons absorbed while the field was active.

It is this relationship between field-strength and frequency that allows the use of nuclear magnetic resonance for imaging. Additional magnetic fields are applied during the scan to make the magnetic field strength depend on the position within the patient, in turn making the frequency of the released photons dependent on position in a predictable manner. Position information can then be recovered from the resulting signal by the use of a Fourier transform In mathematics, the Fourier transform is an operation that transforms one complex-valued function of a real variable into another. In such applications as signal processing, the domain of the original function is typically time and is accordingly called the time domain. The domain of the new function is typically called the frequency domain, and. These fields are created by passing electric currents through specially-wound solenoids A solenoid[nb 1] is a three-dimensional coil wound into a tightly packed helix. In physics, the term solenoid refers to a loop of wire, often wrapped around a metallic core, which produces a magnetic field when an electric current is passed through it. Solenoids are important because they can create controlled magnetic fields and can be used as, known as gradient coils. Since these coils are within the bore of the scanner, there are large forces between them and the main field coils, producing most of the noise that is heard during operation. Without efforts to dampen this noise, it can approach 130 decibels The decibel is a logarithmic unit for the ratio of a physical quantity (usually power or intensity) relative to a specified or implied reference level. A ratio in decibels is ten times the logarithm to base 10 of the ratio of two power quantities. Being a ratio of two measurements of a physical quantity in the same units, it is a dimensionless (dB) with strong fields [7] (see also the subsection on acoustic noise).

An image can be constructed because the protons in different tissues return to their equilibrium state at different rates, which is a difference that can be detected. By changing the parameters on the scanner, this effect is used to create contrast between different types of body tissue or between other properties, as in fMRI Functional MRI or functional Magnetic Resonance Imaging is a type of specialized MRI scan. It measures the hemodynamic response (change in blood flow) related to neural activity in the brain or spinal cord of humans or other animals. It is one of the most recently developed forms of neuroimaging. Since the early 1990s, fMRI has come to dominate and diffusion MRI Diffusion MRI is a magnetic resonance imaging method that produces in vivo images of biological tissues weighted with the local microstructural characteristics of water diffusion.

Contrast agents A medical contrast medium is a substance used to enhance the contrast of structures or fluids within the body in medical imaging. It is commonly used to enhance the visibility of blood vessels and the gastrointestinal tract may be injected intravenously Intravenous therapy or IV therapy is the giving of liquid substances directly into a vein. The word intravenous simply means "within a vein". Therapies administered intravenously are often called specialty pharmaceuticals. It is commonly referred to as a drip because many systems of administration employ a drip chamber, which prevents to enhance the appearance of blood vessels The blood vessels are the part of the circulatory system that transport blood throughout the body. There are three major types of blood vessels: the arteries, which carry the blood away from the heart; the capillaries, which enable the actual exchange of water and chemicals between the blood and the tissues; and the veins, which carry blood from, tumors Neoplasm is an abnormal mass of tissue as a result of neoplasia. Neoplasia is the abnormal proliferation of cells. The growth of the cells exceeds, and is uncoordinated with that of the normal tissues around it. The growth persists in the same excessive manner even after cessation of the stimuli. It usually causes a lump or tumor. Neoplasms may be or inflammation Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process. Inflammation is not a synonym for infection. Even in cases where inflammation is. Contrast agents may also be directly injected into a joint in the case of arthrograms An arthrogram is a series of images, often X-rays, of a joint after injection of a contrast medium. The injection is normally done under a local anesthetic.The radiologist performs the study utilizing fluoroscopy or ultrasound to guide the placement of the needle into the joint and then injects an appropriate quantity of contrast. The physician or, MRI images of joints. Unlike CT Computed tomography is a medical imaging method employing tomography created by computer processing. Digital geometry processing is used to generate a three-dimensional image of the inside of an object from a large series of two-dimensional X-ray images taken around a single axis of rotation, MRI uses no ionizing radiation Ionizing radiation consists of subatomic particles or electromagnetic waves that are energetic enough to detach electrons from atoms or molecules, ionizing them. The occurrence of ionization depends on the energy of the impinging individual particles or waves, and not on their number. An intense flood of particles or waves will not cause and is generally a very safe procedure. Nonetheless the strong magnetic fields and radio pulses can affect metal implants, including cochlear implants A cochlear implant is a surgically implanted electronic device that provides a sense of sound to a person who is profoundly deaf or severely hard of hearing. The cochlear implant is often referred to as a bionic ear and cardiac pacemakers. In the case of cardiac pacemakers, the results can sometimes be lethal,[8] so patients with such implants are generally not eligible for MRI.

MRI is used to image every part of the body, and is particularly useful for tissues with many hydrogen nuclei and little density contrast, such as the brain, muscle Muscle is the contractile tissue of animals and is derived from the mesodermal layer of embryonic germ cells. Muscle cells contain contractile filaments that move past each other and change the size of the cell. They are classified as skeletal, cardiac, or smooth muscles. Their function is to produce force and cause motion. Muscles can cause, connective tissue Connective tissue is a form of fibrous tissue.. It is one of the four types of tissue in traditional classifications and most tumors A tumor or tumour is the name for a neoplasm or a solid lesion formed by an abnormal growth of cells which looks like a swelling. Tumor is not synonymous with cancer. A tumor can be benign, pre-malignant or malignant, whereas cancer is by definition malignant.

Applications

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In clinical practice, MRI is used to distinguish pathologic tissue (such as a brain tumor A brain tumour is an intracranial solid neoplasm, a tumour within the brain or the central spinal canal) from normal tissue. One advantage of an MRI scan is that it is believed to be harmless to the patient. It uses strong magnetic fields and non-ionizing radiation in the radio frequency range, unlike CT scans Computed tomography is a medical imaging method employing tomography created by computer processing. Digital geometry processing is used to generate a three-dimensional image of the inside of an object from a large series of two-dimensional X-ray images taken around a single axis of rotation. MRI-Scanners on the other hand produce about the same and traditional X-rays Radiography is the use of the property of X-rays to cross materials to view inside objects. The impact on society of this technique has been immense with application fields including medical, non-destructive testing, food inspection, security and archeology, which both use ionizing radiation Ionizing radiation consists of subatomic particles or electromagnetic waves that are energetic enough to detach electrons from atoms or molecules, ionizing them. The occurrence of ionization depends on the energy of the impinging individual particles or waves, and not on their number. An intense flood of particles or waves will not cause.

While CT provides good spatial resolution Angular resolution or 'spatial resolution' describes the resolving power of any image-forming device such as an optical or radio telescope, a microscope, a camera, or an eye (the ability to distinguish two separate structures an arbitrarily small distance from each other), MRI provides comparable resolution with far better contrast resolution (the ability to distinguish the differences between two arbitrarily similar but not identical tissues). The basis of this ability is the complex library of pulse sequences that the modern medical MRI scanner includes, each of which is optimized to provide image contrast based on the chemical sensitivity of MRI.

For example, with particular values of the echo time (TE) and the repetition time (TR), which are basic parameters of image acquisition, a sequence takes on the property of T2-weighting. On a T2-weighted scan, water- and fluid-containing tissues are bright (most modern T2 sequences are actually fast T2 sequences) and fat-containing tissues are dark. The reverse is true for T1-weighted images. Damaged tissue tends to develop edema Edema or oedema (British English; both words from the Greek οἴδημα, oídēma "swelling"), formerly known as dropsy or hydropsy, is an abnormal accumulation of fluid beneath the skin or in one or more cavities of the body. Generally, the amount of interstitial fluid is determined by the balance of fluid homeostasis, and increased, which makes a T2-weighted sequence sensitive for pathology, and generally able to distinguish pathologic tissue from normal tissue. With the addition of an additional radio frequency pulse and additional manipulation of the magnetic gradients, a T2-weighted sequence can be converted to a FLAIR sequence, in which free water is now dark, but edematous tissues remain bright. This sequence in particular is currently the most sensitive way to evaluate the brain for demyelinating Myelin is a dielectric material that forms a layer, the myelin sheath, usually around only the axon of a neuron. It is essential for the proper functioning of the nervous system. Myelin is an outgrowth of a glial cell. Schwann cells supply the myelin for peripheral neurons, whereas oligodendrocytes, specifically of the interfascicular type, diseases, such as multiple sclerosis.

The typical MRI examination consists of 5–20 sequences, each of which are chosen to provide a particular type of information about the subject tissues. This information is then synthesized by the interpreting physician.

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A. PET scan echocardiography ultrasound nuclear imaging
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